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MRCPUK SEND dumps - in .pdf

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  • Exam Code: SEND
  • Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
  • Updated: Aug 21, 2026
  • Q & A: 200 Questions and Answers
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  • Exam Code: SEND
  • Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
  • Updated: Aug 21, 2026
  • Q & A: 200 Questions and Answers
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  • Exam Code: SEND
  • Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
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MRCPUK SEND Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Thyroid Disorders15%- Thyroid nodules and cancer
- Hyperthyroidism: Graves’ disease, toxic nodular disease
- Thyroiditis and subclinical dysfunction
- Hypothyroidism and myxoedema coma
Topic 2: Diabetes Mellitus40%- Type 1 Diabetes
  • 1. Long-term microvascular/macrovascular complications
    • 2. Pathogenesis and natural history
      • 3. Insulin therapy and delivery systems
        • 4. Acute complications: DKA, hypoglycaemia
          - Type 2 Diabetes
          • 1. Cardiovascular risk management
            • 2. Epidemiology and risk factors
              • 3. Gestational diabetes
                • 4. Oral and injectable non-insulin therapies
                  - Other forms of diabetes
                  • 1. Monogenic diabetes
                    • 2. Pancreatic/endocrine-induced diabetes
                      Topic 3: Adrenal and Parathyroid/Metabolic Bone Disorders15%- Osteoporosis, osteomalacia, Paget's disease
                      - Cushing's syndrome, Addison's disease, phaeochromocytoma
                      - Primary/secondary hyperaldosteronism
                      - Hyperparathyroidism, hypoparathyroidism
                      Topic 4: Reproductive and Other Endocrine Conditions15%- Endocrine hypertension and rare syndromes
                      - Polycystic ovary syndrome
                      - Disorders of puberty and sex development
                      - Obesity and lipid disorders
                      Topic 5: Pituitary and Hypothalamic Disorders15%- Pituitary adenomas: prolactinoma, acromegaly, Cushing's disease
                      - Hypothalamic dysfunction
                      - Diabetes insipidus and SIADH
                      - Hypopituitarism and hormone replacement

                      MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:

                      1. A 35-year-old woman with a 12-year history of type 1 diabetes mellitus was reviewed in the multidisciplinary pump clinic, because her diabetes was treated with an insulin pump. She had a group 2, C1 lorry-driving licence.
                      Specific driving-related questioning showed that she kept fast-acting carbohydrate in her vehicles and she reported good hypoglycaemic warnings. Data downloaded from her pump indicated significant variability in her blood glucose readings with few results below 2 mmol/L. She declared that this happened occasionally and she was able to explain the events.
                      According to implementation by the UK of the Third European Union Directive on driving, what is the most appropriate advice?

                      A) she can continue to drive
                      B) she should stop driving voluntarily until blood glucose levels increase
                      C) her licence must be surrendered immediately until further assessment
                      D) she must surrender her licence for 6 months
                      E) she must appear before a Driver and Vehicle Licensing Agency-accredited diabetes specialist for assessment within 1 month


                      2. A 64-year-old man, who was undergoing investigation for altered bowel habit, was referred to the endocrine clinic after a CT scan of abdomen had shown a 4-cm mass in his left adrenal gland. He had a history of hypertension and type 2 diabetes mellitus.
                      Investigations:
                      low-dose dexamethasone suppression test (2 mg/day for 48 h):
                      serum cortisol350 nmol/L (<50)
                      24-h urinary free cortisol400 nmol (55-250)
                      plasma adrenocorticotropic hormone (09.00 h)2.0 pmol/L (3.3-15.4)
                      He underwent laparoscopic removal of his left adrenal gland.
                      How should his endocrine condition be managed following surgery?

                      A) immediate postoperative tetracosactide (Synacthen@) test and, if abnormal, start hydrocortisone
                      B) 24-h urinary cortisol 6 weeks postoperatively and start hydrocortisone if abnormally low
                      C) start hydrocortisone perioperatively and continue until tetracosactide (Synacthen@) test in 6 weeks
                      D) tetracosactide (Synacthen@) test 6 weeks postoperatively and start hydrocortisone if abnormal
                      E) introduce hydrocortisone and fludrocortisone postoperatively according to blood pressure and electrolytes


                      3. A 29-year-old woman presented with primary infertility, having had unprotected sexual intercourse for 15 months. Menarche had occurred at the age of 13.5 years. Her menstrual cycle was irregular, occurring every 20-60 days. There was no history of galactorrhoea. She denied abnormal hair growth.
                      On examination, her body mass index was 28.9 kg/m2 (18-25) and she had normal secondary sexual characteristics. Her visual fields were full to confrontation.
                      Investigations:
                      serum androstenedione12.8 nmol/L (0.6-8.8)
                      serum oestradiol205 pmol/L (200-400)
                      serum testosterone2.4 nmol/L (0.5-3.0)
                      serum sex hormone binding globulin23 nmol/L (40-137)
                      serum follicle-stimulating hormone4.3 U/L (2.5-10.0)
                      serum luteinising hormone8.5 U/L (2.5-10.0)
                      serum prolactin420 mU/L (<360)
                      hysterosalpingogrampatent fallopian tubes
                      partner's semen analysisnormal sperm count and motility
                      What is the most appropriate first-line intervention?

                      A) human menopausal gonadotropins
                      B) cabergoline
                      C) human chorionic gonadotropin
                      D) metformin
                      E) orlistat


                      4. A 32-year-old man presented to the fertility clinic with his partner. The couple had been together for 4 years and had been trying to conceive for the past 3 years. His partner had children from a previous marriage.
                      On examination, he was healthy, thin and tall but had bilateral gynaecomastia. His testes felt firm and testicular volumes were 5-6 mL. He had normal pubic and axillary hair.
                      Investigations:
                      serum testosterone10.0 nmol/L (9.0-35.0) plasma follicle-stimulating hormone45.0 U/L (1.0-7.0) plasma luteinising hormone32.0 U/L (1.0-10.0)
                      chromosomal studiesmosaic pattern of 47 XXY/46 XY
                      semen analysisazoospermia testicular biopsyno viable spermatozoa
                      What intervention is most likely to lead to conception?

                      A) intracytoplasmic sperm injection
                      B) testosterone
                      C) artificial insemination by donor
                      D) pulsatile gonadotropin-releasing hormone
                      E) human chorionic gonadotropin


                      5. A 26-year-old man was referred from the sexual health clinic, after small testes had been noted during treatment for genital warts. The patient reported recent loss of libido but there was no history of erectile dysfunction or delayed pubertal development. He was taking no regular medication. Approximately 3 years before presentation, he had taken anabolic steroids for 6 months to improve his muscle bulk.
                      On examination, normal facial, axillary and pubic hair was present. Testicular volume was 6 mL and his testes were firm.
                      Investigations:
                      serum testosterone4.0 nmol/L (9.0-35.0)
                      plasma follicle-stimulating hormone21.0 U/L (1.0-7.0)
                      plasma luteinising hormone23.0 U/L (1.0-10.0)
                      serum prolactin420 mU/L (<360)
                      What is the most likely diagnosis?

                      A) exogenous anabolic steroid use
                      B) microprolactinoma
                      C) haemochromatosis
                      D) Klinefelter's syndrome
                      E) Kallmann's syndrome


                      Solutions:

                      Question # 1
                      Answer: A
                      Question # 2
                      Answer: C
                      Question # 3
                      Answer: D
                      Question # 4
                      Answer: C
                      Question # 5
                      Answer: D

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